Drug interactions
Indacaterol-glycopyrronium + Trimipramine
Severity: Major
Indacaterol-glycopyrronium and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta2-agonists and prolong the QT interval, which may increase the risk of arrhythmia. Trimipramine also has anticholinergic activity that may add to glycopyrronium effects.
What this interaction means in plain words
Indacaterol-glycopyrronium and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indacaterol-glycopyrronium belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Potentiation of adrenergic cardiovascular effects, additive QT prolongation and additive antimuscarinic effects.
What to do
Use with extreme caution, obtain a baseline ECG and monitor heart rate, rhythm and potassium. Watch for anticholinergic effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Trimipramine?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta2-agonists and prolong the QT interval, which may increase the risk of arrhythmia. Trimipramine also has anticholinergic activity that may add to glycopyrronium effects.
How serious is the interaction between Indacaterol-glycopyrronium and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with extreme caution, obtain a baseline ECG and monitor heart rate, rhythm and potassium. Watch for anticholinergic effects.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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