Drug interactions
Indacaterol-glycopyrronium + Valbenazine
Severity: Moderate
Indacaterol-glycopyrronium and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong the QT interval at higher exposures, and indacaterol may contribute to arrhythmic risk. The combination could raise the risk of ventricular arrhythmias in susceptible patients.
What this interaction means in plain words
Indacaterol-glycopyrronium and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Valbenazine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization, with possible beta-2 agonist-induced hypokalemia.
What to do
Monitor ECG and electrolytes in patients with cardiac disease or other QT risk factors. Avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Valbenazine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may prolong the QT interval at higher exposures, and indacaterol may contribute to arrhythmic risk. The combination could raise the risk of ventricular arrhythmias in susceptible patients.
How serious is the interaction between Indacaterol-glycopyrronium and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac disease or other QT risk factors. Avoid additional QT-prolonging drugs.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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