Drug interactions
Infliximab + Rilonacept
Severity: Major
Infliximab and Rilonacept: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infliximab (TNF blocker) and rilonacept (IL-1 blocker) each impair host defense, and combining cytokine inhibitors raises the risk of serious infection. Similar combinations of biologics have shown more infections without added benefit.
What this interaction means in plain words
Infliximab and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Infliximab belongs to Musculoskeletal; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression through simultaneous blockade of TNF-alpha and IL-1 signalling.
What to do
Avoid concurrent use where possible and choose a single biologic. If combined, monitor closely for signs of infection and interrupt therapy if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Infliximab with Rilonacept?
MediHelp rates the interaction as major. Infliximab and Rilonacept can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Infliximab (TNF blocker) and rilonacept (IL-1 blocker) each impair host defense, and combining cytokine inhibitors raises the risk of serious infection. Similar combinations of biologics have shown more infections without added benefit.
How serious is the interaction between Infliximab and Rilonacept?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose a single biologic. If combined, monitor closely for signs of infection and interrupt therapy if a serious infection develops.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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