Drug interactions
Infliximab + Trastuzumab deruxtecan
Severity: Moderate
Infliximab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and infliximab adds immunosuppression, so serious infection risk may rise. No pharmacokinetic interaction is expected.
What this interaction means in plain words
Infliximab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Monitor neutrophil counts and signs of infection. Reconsider infliximab if neutropenia or infection occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Infliximab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Infliximab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and infliximab adds immunosuppression, so serious infection risk may rise. No pharmacokinetic interaction is expected.
How serious is the interaction between Infliximab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection. Reconsider infliximab if neutropenia or infection occurs.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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