Drug interactions
Insulin degludec-insulin aspart + Labetalol
Severity: Moderate
Insulin degludec-insulin aspart and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol can blunt the adrenergic warning symptoms of hypoglycemia, such as tremor and palpitations, and may delay recovery from low glucose. Effects on glycemic control are variable, and sweating is typically preserved.
What this interaction means in plain words
Insulin degludec-insulin aspart and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Labetalol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade masks sympathetic hypoglycemia symptoms and impairs glycogenolysis-mediated glucose recovery.
What to do
Monitor blood glucose regularly and educate the patient that sweating may be the main warning sign of hypoglycemia. Adjust the insulin dose based on glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Labetalol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol can blunt the adrenergic warning symptoms of hypoglycemia, such as tremor and palpitations, and may delay recovery from low glucose. Effects on glycemic control are variable, and sweating is typically preserved.
How serious is the interaction between Insulin degludec-insulin aspart and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly and educate the patient that sweating may be the main warning sign of hypoglycemia. Adjust the insulin dose based on glucose readings.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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