Drug interactions
Insulin degludec-insulin aspart + Liraglutide
Severity: Moderate
Insulin degludec-insulin aspart and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a GLP-1 receptor agonist to insulin improves control but increases the risk of hypoglycemia. Insulin doses often need to be reduced, particularly as appetite and weight fall.
What this interaction means in plain words
Insulin degludec-insulin aspart and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose-lowering: liraglutide enhances glucose-dependent insulin secretion, suppresses glucagon and slows gastric emptying.
What to do
Monitor blood glucose closely and consider reducing the insulin dose when starting or titrating liraglutide. Do not mix liraglutide and insulin in the same injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Liraglutide?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a GLP-1 receptor agonist to insulin improves control but increases the risk of hypoglycemia. Insulin doses often need to be reduced, particularly as appetite and weight fall.
How serious is the interaction between Insulin degludec-insulin aspart and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the insulin dose when starting or titrating liraglutide. Do not mix liraglutide and insulin in the same injection.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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