Drug interactions
Insulin degludec-insulin aspart + Metoprolol
Severity: Moderate
Insulin degludec-insulin aspart and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol can mask adrenergic symptoms of hypoglycemia and may delay glucose recovery in insulin-treated patients. Glycemic effects are variable but clinically manageable.
What this interaction means in plain words
Insulin degludec-insulin aspart and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Metoprolol belongs to Cardiovascular.
Why it happens
Beta-1 selective blockade masks sympathetic warning symptoms and partly impairs glycogenolysis, with less effect than nonselective agents.
What to do
Monitor blood glucose and counsel the patient that sweating may be the only warning sign of hypoglycemia. Adjust insulin dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Metoprolol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol can mask adrenergic symptoms of hypoglycemia and may delay glucose recovery in insulin-treated patients. Glycemic effects are variable but clinically manageable.
How serious is the interaction between Insulin degludec-insulin aspart and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and counsel the patient that sweating may be the only warning sign of hypoglycemia. Adjust insulin dosing as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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