Drug interactions
Insulin degludec-insulin aspart + Paliperidone
Severity: Moderate
Insulin degludec-insulin aspart and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can be associated with hyperglycemia and weight gain, which may worsen glycemic control in patients on insulin. Insulin dose increases may be needed.
What this interaction means in plain words
Insulin degludec-insulin aspart and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Paliperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotic effects on insulin resistance and weight oppose insulin action; mechanism is not fully defined.
What to do
Monitor blood glucose more frequently after starting paliperidone and adjust insulin dosing accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Paliperidone?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can be associated with hyperglycemia and weight gain, which may worsen glycemic control in patients on insulin. Insulin dose increases may be needed.
How serious is the interaction between Insulin degludec-insulin aspart and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting paliperidone and adjust insulin dosing accordingly.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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