Drug interactions
Insulin degludec-insulin aspart + Saxagliptin
Severity: Moderate
Insulin degludec-insulin aspart and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding saxagliptin to insulin improves glycemic control but increases the risk of hypoglycemia. Saxagliptin has also been associated with a signal for heart failure hospitalization.
What this interaction means in plain words
Insulin degludec-insulin aspart and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
DPP-4 inhibition raises incretin levels, enhancing glucose-dependent insulin secretion and lowering glucagon, additive to exogenous insulin.
What to do
Consider lowering the insulin dose when starting saxagliptin and monitor glucose. Monitor for heart failure symptoms in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Saxagliptin?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding saxagliptin to insulin improves glycemic control but increases the risk of hypoglycemia. Saxagliptin has also been associated with a signal for heart failure hospitalization.
How serious is the interaction between Insulin degludec-insulin aspart and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting saxagliptin and monitor glucose. Monitor for heart failure symptoms in at-risk patients.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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