Drug interactions
Insulin degludec-liraglutide + Sotagliflozin
Severity: Moderate
Insulin degludec-liraglutide and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers glucose and adds to the effect of insulin degludec and liraglutide, increasing the risk of hypoglycemia. Ketoacidosis risk also needs attention in patients on insulin.
What this interaction means in plain words
Insulin degludec-liraglutide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT1/SGLT2 inhibition together with insulin and GLP-1 receptor agonism.
What to do
Consider reducing the insulin dose when starting sotagliflozin and monitor glucose closely. Monitor for ketoacidosis symptoms and do not reduce insulin excessively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers glucose and adds to the effect of insulin degludec and liraglutide, increasing the risk of hypoglycemia. Ketoacidosis risk also needs attention in patients on insulin.
How serious is the interaction between Insulin degludec-liraglutide and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting sotagliflozin and monitor glucose closely. Monitor for ketoacidosis symptoms and do not reduce insulin excessively.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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