Drug interactions
Insulin glargine + Linagliptin
Severity: Moderate
Insulin glargine and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to insulin glargine improves glucose control but may increase hypoglycemia. Insulin dose may need to be lowered.
What this interaction means in plain words
Insulin glargine and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering through exogenous insulin and DPP-4 inhibition increasing glucose-dependent insulin secretion.
What to do
Monitor glucose when linagliptin is started or stopped and consider reducing the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin glargine with Linagliptin?
MediHelp rates the interaction as moderate. Insulin glargine and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to insulin glargine improves glucose control but may increase hypoglycemia. Insulin dose may need to be lowered.
How serious is the interaction between Insulin glargine and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when linagliptin is started or stopped and consider reducing the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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