Drug interactions
Insulin glargine + Lixisenatide
Severity: Moderate
Insulin glargine and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide combined with basal insulin increases the risk of hypoglycemia. The combination is used therapeutically but often requires insulin dose reduction.
What this interaction means in plain words
Insulin glargine and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Additive glucose lowering: GLP-1 receptor agonism enhances glucose-dependent insulin secretion and suppresses glucagon alongside exogenous insulin.
What to do
Monitor glucose and reduce the basal insulin dose if hypoglycemia occurs or when starting lixisenatide in well-controlled patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Lixisenatide
Frequently asked questions
Can I take Insulin glargine with Lixisenatide?
MediHelp rates the interaction as moderate. Insulin glargine and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide combined with basal insulin increases the risk of hypoglycemia. The combination is used therapeutically but often requires insulin dose reduction.
How serious is the interaction between Insulin glargine and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce the basal insulin dose if hypoglycemia occurs or when starting lixisenatide in well-controlled patients.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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