Drug interactions
Insulin glargine + Lopinavir
Severity: Moderate
Insulin glargine and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, which is given with ritonavir, can cause insulin resistance and hyperglycemia, so insulin glargine may become less effective. New or worsened diabetes has been reported with protease inhibitors.
What this interaction means in plain words
Insulin glargine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair peripheral glucose uptake and may affect insulin secretion, producing insulin resistance.
What to do
Monitor glucose regularly during therapy and increase the insulin glargine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Insulin glargine with Lopinavir?
MediHelp rates the interaction as moderate. Insulin glargine and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, which is given with ritonavir, can cause insulin resistance and hyperglycemia, so insulin glargine may become less effective. New or worsened diabetes has been reported with protease inhibitors.
How serious is the interaction between Insulin glargine and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose regularly during therapy and increase the insulin glargine dose as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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