Drug interactions
Insulin glargine + Miglitol
Severity: Moderate
Insulin glargine and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol adds to insulin's glucose-lowering effect and can cause hypoglycemia, which must be treated with glucose rather than sucrose.
What this interaction means in plain words
Insulin glargine and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Additive glucose lowering through alpha-glucosidase inhibition delaying carbohydrate absorption plus exogenous insulin.
What to do
Monitor glucose, reduce insulin if hypoglycemia occurs, and advise patients to treat lows with dextrose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Insulin glargine with Miglitol?
MediHelp rates the interaction as moderate. Insulin glargine and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miglitol adds to insulin's glucose-lowering effect and can cause hypoglycemia, which must be treated with glucose rather than sucrose.
How serious is the interaction between Insulin glargine and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, reduce insulin if hypoglycemia occurs, and advise patients to treat lows with dextrose.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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