Drug interactions
Insulin glargine-lixisenatide + Sotagliflozin
Severity: Moderate
Insulin glargine-lixisenatide and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin lowers blood glucose through increased urinary glucose excretion and reduced intestinal glucose absorption. Combined with insulin, it raises the risk of hypoglycemia. Sotagliflozin also carries a risk of ketoacidosis, which can be heightened when insulin doses are reduced.
What this interaction means in plain words
Insulin glargine-lixisenatide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects of SGLT1/SGLT2 inhibition with insulin and lixisenatide.
What to do
Monitor blood glucose and consider lowering the insulin dose when starting sotagliflozin. Avoid excessive insulin reduction and check for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin lowers blood glucose through increased urinary glucose excretion and reduced intestinal glucose absorption. Combined with insulin, it raises the risk of hypoglycemia. Sotagliflozin also carries a risk of ketoacidosis, which can be heightened when insulin doses are reduced.
How serious is the interaction between Insulin glargine-lixisenatide and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider lowering the insulin dose when starting sotagliflozin. Avoid excessive insulin reduction and check for ketoacidosis symptoms.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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