Drug interactions
Insulin isophane protamine human + Sotagliflozin
Severity: Moderate
Insulin isophane protamine human and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding sotagliflozin to insulin lowers glucose further and raises the risk of hypoglycemia. Sotagliflozin also carries a risk of diabetic ketoacidosis, which may be harder to recognize in insulin-treated patients who reduce their insulin too far.
What this interaction means in plain words
Insulin isophane protamine human and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering through insulin action plus SGLT-mediated urinary glucose excretion.
What to do
Consider reducing the insulin dose when starting sotagliflozin and monitor glucose and ketones. Avoid excessive insulin reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding sotagliflozin to insulin lowers glucose further and raises the risk of hypoglycemia. Sotagliflozin also carries a risk of diabetic ketoacidosis, which may be harder to recognize in insulin-treated patients who reduce their insulin too far.
How serious is the interaction between Insulin isophane protamine human and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting sotagliflozin and monitor glucose and ketones. Avoid excessive insulin reduction.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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