Drug interactions
Ipratropium + Tiotropium-olodaterol
Severity: Moderate
Ipratropium and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tiotropium and ipratropium are inhaled antimuscarinic bronchodilators, so using them together duplicates therapy and may add anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and raised intraocular pressure. There is no added bronchodilator benefit that justifies routine combination.
What this interaction means in plain words
Ipratropium and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism from two inhaled anticholinergics.
What to do
Avoid regular concurrent use of ipratropium with tiotropium and stop the short-acting antimuscarinic when the long-acting agent is started. Monitor for anticholinergic adverse effects if the combination is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Ipratropium with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Ipratropium and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both tiotropium and ipratropium are inhaled antimuscarinic bronchodilators, so using them together duplicates therapy and may add anticholinergic effects such as dry mouth, urinary retention, constipation, tachycardia and raised intraocular pressure. There is no added bronchodilator benefit that justifies routine combination.
How serious is the interaction between Ipratropium and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use of ipratropium with tiotropium and stop the short-acting antimuscarinic when the long-acting agent is started. Monitor for anticholinergic adverse effects if the combination is unavoidable.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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