Drug interactions
Ipratropium + Trimipramine
Severity: Minor
Ipratropium and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with significant anticholinergic activity that may add to ipratropium's effects, including dry mouth, constipation and urinary retention. Inhaled ipratropium has low systemic absorption, so the effect is usually modest.
What this interaction means in plain words
Ipratropium and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects, especially in older patients or those with glaucoma or prostatic enlargement.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Ipratropium with Trimipramine?
MediHelp rates the interaction as minor. Ipratropium and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimipramine is a tricyclic antidepressant with significant anticholinergic activity that may add to ipratropium's effects, including dry mouth, constipation and urinary retention. Inhaled ipratropium has low systemic absorption, so the effect is usually modest.
How serious is the interaction between Ipratropium and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older patients or those with glaucoma or prostatic enlargement.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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