Drug interactions
Ipratropium-salbutamol + Leuprolide
Severity: Moderate
Ipratropium-salbutamol and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and salbutamol may add to this through hypokalemia and tachycardia. The added effect of inhaled salbutamol is usually modest. Risk is higher with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Ipratropium-salbutamol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation, with hypokalemia from beta-2 stimulation as a contributor.
What to do
Check electrolytes and consider a baseline ECG in patients with cardiac risk factors. Avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Leuprolide?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can prolong the QT interval, and salbutamol may add to this through hypokalemia and tachycardia. The added effect of inhaled salbutamol is usually modest. Risk is higher with cardiac disease or electrolyte disturbances.
How serious is the interaction between Ipratropium-salbutamol and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and consider a baseline ECG in patients with cardiac risk factors. Avoid excessive salbutamol dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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