Drug interactions
Ipratropium-salbutamol + Pentamidine
Severity: Moderate
Ipratropium-salbutamol and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can cause QT prolongation, torsades de pointes and hypoglycemia or hypokalemia. Salbutamol may add to arrhythmia risk through tachycardia and lowering of potassium.
What this interaction means in plain words
Ipratropium-salbutamol and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a risk factor.
What to do
Monitor ECG and electrolytes when systemic pentamidine is given to patients using salbutamol. Correct potassium and magnesium and limit high-dose salbutamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Pentamidine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can cause QT prolongation, torsades de pointes and hypoglycemia or hypokalemia. Salbutamol may add to arrhythmia risk through tachycardia and lowering of potassium.
How serious is the interaction between Ipratropium-salbutamol and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes when systemic pentamidine is given to patients using salbutamol. Correct potassium and magnesium and limit high-dose salbutamol.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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