Drug interactions
Ipratropium-salbutamol + Prochlorperazine
Severity: Minor
Ipratropium-salbutamol and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has anticholinergic activity and can prolong QT, and salbutamol at high doses can add to QT risk through hypokalemia. Inhaled ipratropium has low systemic exposure, so the additive anticholinergic effect is small.
What this interaction means in plain words
Ipratropium-salbutamol and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ipratropium-salbutamol belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Weak additive anticholinergic effects and possible additive QT effects.
What to do
No routine changes needed; monitor ECG and potassium if high-dose salbutamol is used or other QT risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Ipratropium-salbutamol with Prochlorperazine?
MediHelp rates the interaction as minor. Ipratropium-salbutamol and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine has anticholinergic activity and can prolong QT, and salbutamol at high doses can add to QT risk through hypokalemia. Inhaled ipratropium has low systemic exposure, so the additive anticholinergic effect is small.
How serious is the interaction between Ipratropium-salbutamol and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine changes needed; monitor ECG and potassium if high-dose salbutamol is used or other QT risk factors exist.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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