Drug interactions
Ipratropium-salbutamol + Toremifene
Severity: Moderate
Ipratropium-salbutamol and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene prolongs the QT interval in a dose-related manner, and salbutamol can add to this through tachycardia and hypokalemia. The combination may raise the risk of torsades de pointes, particularly with frequent or high-dose salbutamol use.
What this interaction means in plain words
Ipratropium-salbutamol and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Toremifene belongs to Endocrine.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Correct hypokalemia and hypomagnesemia before and during treatment, and monitor ECG in patients using salbutamol regularly. Limit salbutamol to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Toremifene?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene prolongs the QT interval in a dose-related manner, and salbutamol can add to this through tachycardia and hypokalemia. The combination may raise the risk of torsades de pointes, particularly with frequent or high-dose salbutamol use.
How serious is the interaction between Ipratropium-salbutamol and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia before and during treatment, and monitor ECG in patients using salbutamol regularly. Limit salbutamol to the lowest effective dose.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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