Drug interactions
Isavuconazonium + Progesterone
Severity: Minor
Isavuconazonium and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone is unlikely to affect isavuconazole meaningfully, as it is only a weak CYP3A inhibitor. Isavuconazole itself is a moderate CYP3A4 inhibitor and may raise progesterone, which is the more relevant direction.
What this interaction means in plain words
Isavuconazonium and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Progesterone belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by progesterone; isavuconazole in turn moderately inhibits CYP3A4.
What to do
No dose change is generally required. Watch for progestogenic adverse effects during antifungal therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Progesterone?
MediHelp rates the interaction as minor. Isavuconazonium and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone is unlikely to affect isavuconazole meaningfully, as it is only a weak CYP3A inhibitor. Isavuconazole itself is a moderate CYP3A4 inhibitor and may raise progesterone, which is the more relevant direction.
How serious is the interaction between Isavuconazonium and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Watch for progestogenic adverse effects during antifungal therapy.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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