Drug interactions
Selegiline + Solriamfetol
Severity: Contraindicated
Selegiline and Solriamfetol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol raises dopamine and norepinephrine activity, and with MAO inhibitors may cause hypertensive reactions. Labeling prohibits use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Selegiline and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Selegiline belongs to Central Nervous System; Solriamfetol belongs to Central Nervous System.
Why it happens
Solriamfetol blocks dopamine and norepinephrine reuptake while MAO inhibition prevents their breakdown, causing additive pressor effects.
What to do
Do not coadminister. Wait at least 14 days after stopping an MAOI before starting solriamfetol.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Selegiline with Solriamfetol?
MediHelp rates the interaction as contraindicated. Selegiline and Solriamfetol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol raises dopamine and norepinephrine activity, and with MAO inhibitors may cause hypertensive reactions. Labeling prohibits use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Selegiline and Solriamfetol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Wait at least 14 days after stopping an MAOI before starting solriamfetol.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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