Drug interactions
Isoproterenol + Prochlorperazine
Severity: Moderate
Isoproterenol and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine alpha blockade can add to the vasodilation and hypotension caused by beta-agonist stimulation, and both drugs can provoke arrhythmias. The interaction is poorly characterized.
What this interaction means in plain words
Isoproterenol and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade adds to beta-mediated vasodilation; additive proarrhythmic effects are possible but not well established.
What to do
Monitor blood pressure, heart rate and ECG during isoproterenol therapy. Adjust the infusion to hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Prochlorperazine?
MediHelp rates the interaction as moderate. Isoproterenol and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine alpha blockade can add to the vasodilation and hypotension caused by beta-agonist stimulation, and both drugs can provoke arrhythmias. The interaction is poorly characterized.
How serious is the interaction between Isoproterenol and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG during isoproterenol therapy. Adjust the infusion to hemodynamic response.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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