Drug interactions
Istradefylline + Mitomycin
Severity: Minor
Istradefylline and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline can inhibit P-glycoprotein and raise exposure to P-gp substrates. Mitomycin is a P-gp substrate, so higher systemic levels and greater myelosuppression or other toxicity are theoretically possible. The clinical significance with mitomycin has not been well characterized.
What this interaction means in plain words
Istradefylline and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Mitomycin belongs to Oncology.
Why it happens
Istradefylline inhibits P-glycoprotein efflux, potentially reducing mitomycin transport and clearance.
What to do
Monitor blood counts and signs of mitomycin toxicity when starting or stopping istradefylline. Consider mitomycin dose reduction if unexpected toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Mitomycin?
MediHelp rates the interaction as minor. Istradefylline and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline can inhibit P-glycoprotein and raise exposure to P-gp substrates. Mitomycin is a P-gp substrate, so higher systemic levels and greater myelosuppression or other toxicity are theoretically possible. The clinical significance with mitomycin has not been well characterized.
How serious is the interaction between Istradefylline and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of mitomycin toxicity when starting or stopping istradefylline. Consider mitomycin dose reduction if unexpected toxicity develops.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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