Drug interactions
Istradefylline + Rolapitant
Severity: Minor
Istradefylline and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg daily is a weak CYP3A4 inhibitor and may raise concentrations of CYP3A4 substrates. Rolapitant is only a minor CYP3A4 substrate, so any effect on it is likely small.
What this interaction means in plain words
Istradefylline and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Istradefylline at higher doses weakly inhibits CYP3A4, which could slightly slow rolapitant metabolism.
What to do
No dose adjustment is usually required. Be aware of the interaction if istradefylline 40 mg daily is used and rolapitant adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Rolapitant?
MediHelp rates the interaction as minor. Istradefylline and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg daily is a weak CYP3A4 inhibitor and may raise concentrations of CYP3A4 substrates. Rolapitant is only a minor CYP3A4 substrate, so any effect on it is likely small.
How serious is the interaction between Istradefylline and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Be aware of the interaction if istradefylline 40 mg daily is used and rolapitant adverse effects appear.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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