Drug interactions
Istradefylline + Silodosin
Severity: Moderate
Istradefylline and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline can raise exposure to P-glycoprotein substrates, and silodosin is one such substrate. Higher silodosin levels may increase hypotension and dizziness.
What this interaction means in plain words
Istradefylline and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Silodosin belongs to Genitourinary.
Why it happens
Istradefylline inhibits P-glycoprotein, reducing silodosin efflux and increasing its exposure.
What to do
Monitor blood pressure and orthostatic symptoms during co-treatment. Consider lowering the silodosin dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Silodosin?
MediHelp rates the interaction as moderate. Istradefylline and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline can raise exposure to P-glycoprotein substrates, and silodosin is one such substrate. Higher silodosin levels may increase hypotension and dizziness.
How serious is the interaction between Istradefylline and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during co-treatment. Consider lowering the silodosin dose if adverse effects emerge.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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