Drug interactions
Istradefylline + Tenofovir alafenamide
Severity: Minor
Istradefylline and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and has increased exposure of P-gp substrates in clinical studies. Tenofovir alafenamide absorption may therefore increase, raising tenofovir exposure.
What this interaction means in plain words
Istradefylline and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Istradefylline inhibits P-gp efflux of tenofovir alafenamide in the intestine.
What to do
No routine adjustment is needed. Monitor for tenofovir-related adverse effects, including renal function, if the combination is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Istradefylline and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses inhibits P-glycoprotein and has increased exposure of P-gp substrates in clinical studies. Tenofovir alafenamide absorption may therefore increase, raising tenofovir exposure.
How serious is the interaction between Istradefylline and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for tenofovir-related adverse effects, including renal function, if the combination is used.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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