Drug interactions
Itraconazole + Lenvatinib
Severity: Moderate
Itraconazole and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so the combination may add to the risk of ventricular arrhythmias. Itraconazole is not expected to alter lenvatinib pharmacokinetics substantially.
What this interaction means in plain words
Itraconazole and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Monitor ECG and electrolytes (potassium, magnesium, calcium) and correct abnormalities. Consider an alternative antifungal in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Itraconazole with Lenvatinib?
MediHelp rates the interaction as moderate. Itraconazole and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so the combination may add to the risk of ventricular arrhythmias. Itraconazole is not expected to alter lenvatinib pharmacokinetics substantially.
How serious is the interaction between Itraconazole and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes (potassium, magnesium, calcium) and correct abnormalities. Consider an alternative antifungal in patients with other QT risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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