Drug interactions
Itraconazole + Levamlodipine
Severity: Moderate
Itraconazole and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises amlodipine-type exposure, which may cause hypotension, peripheral edema and reflex tachycardia. Itraconazole itself has negative inotropic effects and can worsen edema and heart failure risk with calcium channel blockers.
What this interaction means in plain words
Itraconazole and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Levamlodipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated levamlodipine metabolism, with additive negative inotropic and vasodilatory effects.
What to do
Monitor blood pressure and edema, and reduce the levamlodipine dose if needed. Take care in patients with heart failure or reduced ventricular function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Itraconazole with Levamlodipine?
MediHelp rates the interaction as moderate. Itraconazole and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole raises amlodipine-type exposure, which may cause hypotension, peripheral edema and reflex tachycardia. Itraconazole itself has negative inotropic effects and can worsen edema and heart failure risk with calcium channel blockers.
How serious is the interaction between Itraconazole and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the levamlodipine dose if needed. Take care in patients with heart failure or reduced ventricular function.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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