Drug interactions
Itraconazole + Linagliptin
Severity: Minor
Itraconazole and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly increase linagliptin exposure. Linagliptin has a wide safety margin, so clinically important effects are unlikely.
What this interaction means in plain words
Itraconazole and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Linagliptin belongs to Endocrine.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, which contribute to linagliptin elimination.
What to do
No dose adjustment is needed; continue routine glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Itraconazole with Linagliptin?
MediHelp rates the interaction as minor. Itraconazole and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may modestly increase linagliptin exposure. Linagliptin has a wide safety margin, so clinically important effects are unlikely.
How serious is the interaction between Itraconazole and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue routine glucose monitoring.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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