Drug interactions
Itraconazole + Loratadine
Severity: Minor
Itraconazole and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 and P-glycoprotein inhibitor and can raise loratadine and its active metabolite desloratadine concentrations. Loratadine has a wide safety margin, and studies with potent CYP3A4 inhibitors have shown no meaningful QT effect, so the change is usually of limited clinical importance.
What this interaction means in plain words
Itraconazole and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Loratadine belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by itraconazole reduces loratadine clearance.
What to do
No dose change is normally needed; be aware of possible increased drowsiness or antihistamine side effects. If symptoms occur, consider a lower dose or a different antihistamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Loratadine?
MediHelp rates the interaction as minor. Itraconazole and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole is a strong CYP3A4 and P-glycoprotein inhibitor and can raise loratadine and its active metabolite desloratadine concentrations. Loratadine has a wide safety margin, and studies with potent CYP3A4 inhibitors have shown no meaningful QT effect, so the change is usually of limited clinical importance.
How serious is the interaction between Itraconazole and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; be aware of possible increased drowsiness or antihistamine side effects. If symptoms occur, consider a lower dose or a different antihistamine.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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