Drug interactions
Itraconazole + Mirtazapine
Severity: Moderate
Itraconazole and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase mirtazapine concentrations, causing more sedation and other adverse effects. Both drugs have been linked to QT prolongation, adding to arrhythmia risk.
What this interaction means in plain words
Itraconazole and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Mirtazapine belongs to Central Nervous System.
Why it happens
Itraconazole inhibits CYP3A4 metabolism of mirtazapine, with additive QT effects.
What to do
Monitor for sedation and consider a lower mirtazapine dose. Check ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Itraconazole with Mirtazapine?
MediHelp rates the interaction as moderate. Itraconazole and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase mirtazapine concentrations, causing more sedation and other adverse effects. Both drugs have been linked to QT prolongation, adding to arrhythmia risk.
How serious is the interaction between Itraconazole and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and consider a lower mirtazapine dose. Check ECG in patients with QT risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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