Drug interactions
Itraconazole + Modafinil
Severity: Minor
Itraconazole and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly raise modafinil concentrations. Possible effects include insomnia, anxiety, headache and increased blood pressure or heart rate.
What this interaction means in plain words
Itraconazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Modafinil belongs to Central Nervous System.
Why it happens
Itraconazole inhibits CYP3A4, a secondary pathway of modafinil metabolism.
What to do
No routine dose change is required; monitor for stimulant-related adverse effects and reduce the modafinil dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Itraconazole with Modafinil?
MediHelp rates the interaction as minor. Itraconazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may modestly raise modafinil concentrations. Possible effects include insomnia, anxiety, headache and increased blood pressure or heart rate.
How serious is the interaction between Itraconazole and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for stimulant-related adverse effects and reduce the modafinil dose if they occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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