Drug interactions
Itraconazole + Nevirapine
Severity: Moderate
Itraconazole and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine is a CYP3A4 inducer and typically lowers itraconazole concentrations, risking antifungal failure. Itraconazole may modestly raise nevirapine levels, which could increase hepatotoxicity and rash.
What this interaction means in plain words
Itraconazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 and reduces itraconazole exposure, while itraconazole inhibits CYP3A4 and can increase nevirapine levels.
What to do
Monitor itraconazole concentrations and clinical antifungal response, increasing the dose if needed. Monitor liver function and for nevirapine adverse effects; consider an alternative antifungal if levels remain low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Itraconazole with Nevirapine?
MediHelp rates the interaction as moderate. Itraconazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine is a CYP3A4 inducer and typically lowers itraconazole concentrations, risking antifungal failure. Itraconazole may modestly raise nevirapine levels, which could increase hepatotoxicity and rash.
How serious is the interaction between Itraconazole and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor itraconazole concentrations and clinical antifungal response, increasing the dose if needed. Monitor liver function and for nevirapine adverse effects; consider an alternative antifungal if levels remain low.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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