Drug interactions
Itraconazole + Omaveloxolone
Severity: Major
Itraconazole and Omaveloxolone: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises omaveloxolone exposure through inhibition of its CYP3A4 metabolism. This may increase adverse effects including liver enzyme elevations, nausea and fatigue.
What this interaction means in plain words
Itraconazole and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Omaveloxolone belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition decreases omaveloxolone clearance.
What to do
Avoid coadministration when possible. If needed, reduce omaveloxolone to the labeled lower dose and monitor liver enzymes and tolerability, stopping if adverse effects develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Itraconazole with Omaveloxolone?
MediHelp rates the interaction as major. Itraconazole and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises omaveloxolone exposure through inhibition of its CYP3A4 metabolism. This may increase adverse effects including liver enzyme elevations, nausea and fatigue.
How serious is the interaction between Itraconazole and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration when possible. If needed, reduce omaveloxolone to the labeled lower dose and monitor liver enzymes and tolerability, stopping if adverse effects develop.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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