Drug interactions
Itraconazole + Ozanimod
Severity: Moderate
Itraconazole and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction and may affect QT, and itraconazole can prolong QTc. The combination may increase arrhythmia risk, particularly in patients with cardiac disease.
What this interaction means in plain words
Itraconazole and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and conduction; the interaction is largely pharmacodynamic.
What to do
Check a baseline ECG and monitor for bradycardia and QT prolongation. Avoid in patients with other QT risk factors or choose an alternative antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Itraconazole with Ozanimod?
MediHelp rates the interaction as moderate. Itraconazole and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction and may affect QT, and itraconazole can prolong QTc. The combination may increase arrhythmia risk, particularly in patients with cardiac disease.
How serious is the interaction between Itraconazole and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor for bradycardia and QT prolongation. Avoid in patients with other QT risk factors or choose an alternative antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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