Drug interactions
Itraconazole + Polatuzumab vedotin
Severity: Moderate
Itraconazole and Polatuzumab vedotin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise exposure to unconjugated MMAE, the cytotoxic payload released from polatuzumab vedotin. This could increase toxicities such as neutropenia and peripheral neuropathy.
What this interaction means in plain words
Itraconazole and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Polatuzumab vedotin belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces the metabolism of MMAE, a CYP3A4 substrate.
What to do
Monitor closely for neutropenia, infections and neuropathy during co-therapy. Consider an antifungal with less CYP3A4 inhibition if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Itraconazole with Polatuzumab vedotin?
MediHelp rates the interaction as moderate. Itraconazole and Polatuzumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may raise exposure to unconjugated MMAE, the cytotoxic payload released from polatuzumab vedotin. This could increase toxicities such as neutropenia and peripheral neuropathy.
How serious is the interaction between Itraconazole and Polatuzumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, infections and neuropathy during co-therapy. Consider an antifungal with less CYP3A4 inhibition if feasible.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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