Drug interactions
Itraconazole + Risperidone
Severity: Moderate
Itraconazole and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise the concentration of risperidone's active moiety and both drugs can prolong the QTc interval. This may cause more extrapyramidal symptoms, sedation, hypotension and arrhythmia risk.
What this interaction means in plain words
Itraconazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Risperidone belongs to Central Nervous System.
Why it happens
P-glycoprotein and CYP3A4 inhibition reduces risperidone clearance, plus additive QT effects.
What to do
Monitor for extrapyramidal and cardiovascular effects and consider reducing the risperidone dose. Obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Itraconazole with Risperidone?
MediHelp rates the interaction as moderate. Itraconazole and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can raise the concentration of risperidone's active moiety and both drugs can prolong the QTc interval. This may cause more extrapyramidal symptoms, sedation, hypotension and arrhythmia risk.
How serious is the interaction between Itraconazole and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal and cardiovascular effects and consider reducing the risperidone dose. Obtain an ECG in patients with other QT risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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