Drug interactions
Itraconazole + Ruxolitinib
Severity: Major
Itraconazole and Ruxolitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases ruxolitinib exposure, raising the risk of cytopenias such as thrombocytopenia and neutropenia and infection.
What this interaction means in plain words
Itraconazole and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Ruxolitinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces ruxolitinib clearance.
What to do
Reduce the ruxolitinib dose per labeling when a strong CYP3A4 inhibitor is required, and monitor blood counts frequently. Avoid use in patients with low platelet counts as indicated in the labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Itraconazole with Ruxolitinib?
MediHelp rates the interaction as major. Itraconazole and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases ruxolitinib exposure, raising the risk of cytopenias such as thrombocytopenia and neutropenia and infection.
How serious is the interaction between Itraconazole and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose per labeling when a strong CYP3A4 inhibitor is required, and monitor blood counts frequently. Avoid use in patients with low platelet counts as indicated in the labeling.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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