Drug interactions
Itraconazole + Sevoflurane
Severity: Moderate
Itraconazole and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them during anesthesia may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
What this interaction means in plain words
Itraconazole and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac repolarizing potassium currents leading to QT prolongation.
What to do
Check the baseline ECG and correct potassium and magnesium before surgery in patients on itraconazole. Monitor the ECG continuously during anesthesia and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Itraconazole with Sevoflurane?
MediHelp rates the interaction as moderate. Itraconazole and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining them during anesthesia may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbances, bradycardia or underlying heart disease.
How serious is the interaction between Itraconazole and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline ECG and correct potassium and magnesium before surgery in patients on itraconazole. Monitor the ECG continuously during anesthesia and avoid other QT-prolonging drugs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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