Drug interactions
Itraconazole + Upadacitinib
Severity: Moderate
Itraconazole and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises upadacitinib exposure, which may increase the risk of infection and other dose-related adverse effects. Labeling advises a lower upadacitinib dose with strong CYP3A4 inhibitors.
What this interaction means in plain words
Itraconazole and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Upadacitinib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated upadacitinib metabolism.
What to do
Use the reduced upadacitinib dose recommended in labeling for strong CYP3A4 inhibitors and monitor for infection and laboratory abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Itraconazole with Upadacitinib?
MediHelp rates the interaction as moderate. Itraconazole and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole raises upadacitinib exposure, which may increase the risk of infection and other dose-related adverse effects. Labeling advises a lower upadacitinib dose with strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced upadacitinib dose recommended in labeling for strong CYP3A4 inhibitors and monitor for infection and laboratory abnormalities.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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