Drug interactions
Ivacaftor + Ondansetron
Severity: Minor
Ivacaftor and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and could raise exposure to P-gp substrates. Ondansetron is only partly dependent on P-gp, so any increase is likely small.
What this interaction means in plain words
Ivacaftor and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of P-glycoprotein efflux by ivacaftor may increase ondansetron absorption and exposure.
What to do
No dose adjustment is generally needed. Monitor for ondansetron adverse effects and consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Ondansetron?
MediHelp rates the interaction as minor. Ivacaftor and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and could raise exposure to P-gp substrates. Ondansetron is only partly dependent on P-gp, so any increase is likely small.
How serious is the interaction between Ivacaftor and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for ondansetron adverse effects and consider an ECG if other QT risk factors are present.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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