Drug interactions
Ivacaftor + Ranolazine
Severity: Moderate
Ivacaftor and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite weakly inhibit P-gp and may increase ranolazine exposure. This could heighten dose-related effects such as dizziness, nausea and QT prolongation.
What this interaction means in plain words
Ivacaftor and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Ranolazine belongs to Cardiovascular.
Why it happens
Ivacaftor inhibits P-glycoprotein efflux of ranolazine.
What to do
Monitor for ranolazine adverse effects and consider a lower ranolazine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Ranolazine?
MediHelp rates the interaction as moderate. Ivacaftor and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its metabolite weakly inhibit P-gp and may increase ranolazine exposure. This could heighten dose-related effects such as dizziness, nausea and QT prolongation.
How serious is the interaction between Ivacaftor and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ranolazine adverse effects and consider a lower ranolazine dose if they occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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