Drug interactions
Ivacaftor + Risperidone
Severity: Minor
Ivacaftor and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and may modestly raise risperidone exposure. The effect is usually small, but dose-related adverse effects such as sedation and extrapyramidal symptoms may become more likely.
What this interaction means in plain words
Ivacaftor and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Ivacaftor inhibition of P-glycoprotein, increasing risperidone absorption and exposure.
What to do
Monitor for sedation and extrapyramidal symptoms after ivacaftor is started. Adjust the risperidone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Risperidone?
MediHelp rates the interaction as minor. Ivacaftor and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-glycoprotein and may modestly raise risperidone exposure. The effect is usually small, but dose-related adverse effects such as sedation and extrapyramidal symptoms may become more likely.
How serious is the interaction between Ivacaftor and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and extrapyramidal symptoms after ivacaftor is started. Adjust the risperidone dose if needed.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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