Drug interactions
Ivermectin + Ritonavir
Severity: Minor
Ivermectin and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and P-glycoprotein and may increase ivermectin exposure. Ivermectin's wide therapeutic index limits the likelihood of serious toxicity, but CNS effects are theoretically possible.
What this interaction means in plain words
Ivermectin and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 metabolism and P-glycoprotein efflux of ivermectin.
What to do
No routine dose change is needed. Monitor for dizziness, ataxia or other CNS effects, particularly with repeated dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ivermectin with Ritonavir?
MediHelp rates the interaction as minor. Ivermectin and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir inhibits CYP3A4 and P-glycoprotein and may increase ivermectin exposure. Ivermectin's wide therapeutic index limits the likelihood of serious toxicity, but CNS effects are theoretically possible.
How serious is the interaction between Ivermectin and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, ataxia or other CNS effects, particularly with repeated dosing.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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