Drug interactions
Ivermectin + Verapamil
Severity: Minor
Ivermectin and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a well-known P-glycoprotein inhibitor and may increase ivermectin exposure, including in the central nervous system. Clinical effects are not well documented at standard doses.
What this interaction means in plain words
Ivermectin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-glycoprotein efflux of ivermectin.
What to do
No routine adjustment is needed; monitor for dizziness, ataxia or confusion if ivermectin is given at high or repeated doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Ivermectin with Verapamil?
MediHelp rates the interaction as minor. Ivermectin and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil is a well-known P-glycoprotein inhibitor and may increase ivermectin exposure, including in the central nervous system. Clinical effects are not well documented at standard doses.
How serious is the interaction between Ivermectin and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for dizziness, ataxia or confusion if ivermectin is given at high or repeated doses.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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