Drug interactions
Ixekizumab + Sirolimus
Severity: Minor
Ixekizumab and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixekizumab, by reducing IL-17-driven inflammation, might restore CYP activity suppressed by cytokines. This could slightly lower sirolimus levels, but a clinically significant effect is not established.
What this interaction means in plain words
Ixekizumab and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Theoretical normalisation of cytokine-suppressed CYP3A4 expression.
What to do
Consider checking sirolimus trough levels after starting or stopping ixekizumab and adjust the dose if outside the target range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ixekizumab and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Ixekizumab
- Ixekizumab + Measles mumps and rubella vaccine Major
- Ixekizumab + Upadacitinib Major
- Ifosfamide + Ixekizumab Moderate
- Ixekizumab + Lomustine Moderate
- Carbamazepine + Ixekizumab Minor
- Cyclosporin + Ixekizumab Minor
Frequently asked questions
Can I take Ixekizumab with Sirolimus?
MediHelp rates the interaction as minor. Ixekizumab and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ixekizumab, by reducing IL-17-driven inflammation, might restore CYP activity suppressed by cytokines. This could slightly lower sirolimus levels, but a clinically significant effect is not established.
How serious is the interaction between Ixekizumab and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking sirolimus trough levels after starting or stopping ixekizumab and adjust the dose if outside the target range.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
