Drug interactions
Ketoconazole + Mirvetuximab soravtansine
Severity: Moderate
Ketoconazole and Mirvetuximab soravtansine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may increase exposure to DM4, the cytotoxic payload released from mirvetuximab soravtansine. This could increase toxicities such as ocular, hepatic and hematologic adverse effects.
What this interaction means in plain words
Ketoconazole and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Mirvetuximab soravtansine belongs to Oncology.
Why it happens
Ketoconazole inhibits CYP3A4-mediated metabolism of the DM4 payload.
What to do
Monitor closely for adverse reactions, especially ocular toxicity and neuropathy, and consider an alternative antifungal that is not a strong CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Mirvetuximab soravtansine
Frequently asked questions
Can I take Ketoconazole with Mirvetuximab soravtansine?
MediHelp rates the interaction as moderate. Ketoconazole and Mirvetuximab soravtansine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may increase exposure to DM4, the cytotoxic payload released from mirvetuximab soravtansine. This could increase toxicities such as ocular, hepatic and hematologic adverse effects.
How serious is the interaction between Ketoconazole and Mirvetuximab soravtansine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions, especially ocular toxicity and neuropathy, and consider an alternative antifungal that is not a strong CYP3A4 inhibitor.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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